Anti-centriole antibody: An infectious or autoimmune process?

Biman Saikia, Yashwant Kumar, Ranjana W Minz, Seema Chhabra

Indian Journal of Allergy, Asthma and Immunology 2015 29(2):84-87

Anti-centriolar pattern of staining by indirect immunofluorescence (IIF) on human epithelial type 2 (Hep2) cells is rarely observed, mostly in association with scleroderma and scleroderma-like connective tissue disorders. This paper describes four patients with anti-centriole antibody positivity along with a review of the available literature. In this retrospective study, a total of four cases whose serum showed the centriolar pattern on Hep2 cell lines during IIF examination were reviewed. The presence of anti-centriole antibody in the serum should herald the diagnosis of scleroderma spectrum; Raynaud's phenomenon and pulmonary arterial hypertension should be specifically looked for. In the absence of features of autoimmunity, patients should be screened for Mycoplasma infection.

from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1U4LwMT
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TNUQVR
via IFTTT