Interaction between Esophageal Squamous Cell Carcinoma and Adipose Tissue

Esophageal squamous cell carcinoma (ESCC) develops within the squamous epithelial layer and progressively invades the submucosa to the subadventitia that has abundant adipose tissue (AT). AT seems critical to ESCC progression, but the underlying mechanism is unknown. We aimed to address the association between ESCC and AT in vitro. ESCC cells were cultured on rat or human subcutaneous AT-embedded or –non-embedded collagen gel. AT promoted the growth of ESCC cells and inhibited their apoptosis. AT promoted the expression of the squamous differentiation marker involucrin in ESCC cells. (Source: American Journal of Pathology)

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