Normal pressure hydrocephalus: Increase of utricular input in responders to spinal tap test

Publication date: May 2016
Source:Clinical Neurophysiology, Volume 127, Issue 5
Author(s): N. Böttcher, T. Bremova, K. Feil, C. Heinze, R. Schniepp, M. Strupp
ObjectiveTo investigate whether there is a change in ocular (oVEMP) and cervical (cVEMP) vestibular evoked myogenic potentials in patients with normal pressure hydrocephalus (NPH) before and after spinal tap test (STT).MethodsIn 25 patients (6 females, age 62–83years) c/oVEMP were measured before and after STT. Patients with an increase of >20% of walking velocity were classified as responders (n=10). VEMP were also measured in a control group of 13 non-NPH patients.ResultsAll patients had reproducible oVEMP; 68% had cVEMP. There was a significant increase of the peak-to-peak (pp) oVEMP amplitude after STT in responders (8.5±2.7 to 18.9±7.5μV (p=0.010)). No significant changes were found in non-responders (13.4±7.6 to 15.3±8.6μV) or controls (12.4±7.6 to 12.5±6.8μV). There were no significant differences in cVEMP before and after spinal tap test (STT).ConclusionOne third of patients with suspected NPH had impaired otolith function. Responders to STT only had a significant increase of oVEMP and thereby utricular input, probably due to a decrease of pressure.SignificanceBoth findings indicate that otolith dysfunction may contribute to imbalance in NPH and that increased utricular function after STT may be relevant for gait improvement.

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