Adjuvant interferon-[alpha]2b (IFN-[alpha]2b) has been studied extensively in clinical trials, but there have been few studies of real-world use. The aim of this study is to describe the IFN-[alpha]2b real-world patterns in patients with high-risk melanoma in Spain. This was a retrospective and multicentre chart review study of an unselected cohort of patients with melanoma at high risk for relapse (stage IIB/IIC/III) treated with IFN-[alpha]2b. Patterns were assessed in terms of dose and compliance to planned treatment. A survival analysis was carried out for the full population and according to Kirkwood scheme compliance and the presence of ulceration. Of 327 patients treated with IFN-[alpha]2b, 318 received a high-dose regimen following the standard Kirkwood scheme; thus, patterns are described for this regimen. A total of 121 (38%) and 88 (28%) patients had at least one dose reduction during the induction and maintenance phases, respectively. Dose delay was required in fewer than 10% of patients. A total of 78, 40 and 38% of the patients completed the induction phase, maintenance phase and completed treatment, respectively. The median progression-free and overall survival for the full population were 3.2 and 10.5 years, respectively. There were no differences in progression-free survival and overall survival according to Kirkwood scheme compliance and the presence of ulceration. The most frequent adverse events were neutropenia (31%) and fatigue (30%). High-dose IFN-[alpha]2b is the most frequently used regimen in Spain as an adjuvant systemic treatment for high-risk melanoma. Despite poor compliance, in this retrospective study, IFN-[alpha]2b treatment provided a benefit consistent with that described previously. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://ift.tt/1hexVwJ. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
from melanoma2 via als.fakia on Inoreader http://ift.tt/1pez7ZU
via IFTTT
from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RFALus
via IFTTT
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
▼
2016
(16402)
- ► Δεκεμβρίου (7478)
-
▼
Μαρτίου
(850)
-
▼
Μαρ 12
(50)
- Genetic progression of malignant melanoma
- miR clusters target cellular functional complexes ...
- Personalized treatment of advanced non-small-cell ...
- Shear Wave Elastography and Cervical Lymph Nodes: ...
- Risk of second cancers in the era of modern radiat...
- Characterization of class II β chain major histoco...
- In Memoriam: Dr. William John Garrett, AM
- Presenting hydrothorax predicts failure of needle ...
- Do trauma patients with phencyclidine positive uri...
- Gap Between Official Guidelines and Clinical Pract...
- Error Rates, Decisive Outcomes and Publication Bia...
- Renal cell carcinoma: staging and surveillance
- Imaging wisely: patient safety in CT
- Abdominal radiology in the era of the Intervention...
- Comparison of hepatocellular carcinoma conspicuity...
- The “manta ray” pelvis
- The emotional rollercoaster of battling cancer – P...
- THYROID STIMULATING ANTIBODIES ARE HIGHLY PREVALEN...
- Ethical Considerations When Counseling Patients Wi...
- Utility of Diagnostic Molecular Markers for Evalua...
- Ethical Considerations When Counseling Patients Wi...
- En bloc resection of a C-1 lateral mass osteosarco...
- The Preventable Shunt Revision Rate: a potential q...
- Implications of patient-borne costs associated wit...
- Anti-CD137 monoclonal antibodies and adoptive T ce...
- Fate of Coiled Aneurysms with Minor Recanalization...
- Endovascular Management of Tandem Occlusion Stroke...
- Performance of CT ASPECTS and Collateral Score in ...
- Evaluating Permeability Surface-Area Product as a ...
- Quantitative Susceptibility Mapping in Cerebral Ca...
- Risk factors for persistent disease in papillary t...
- Rise in differentiated thyroid cancer incidence in...
- Treatment patterns of adjuvant interferon-[alpha]2...
- The Merits of a Two-Day Evidence-Based Medicine Co...
- Risk factors for persistent disease in papillary t...
- Assessment of Vibratory Characteristics in Childre...
- MULTIFOCAL CHOROIDITIS IN DISSEMINATED SPOROTRICHO...
- Patterns of lymphatic spread and the management of...
- Bilateral haemorrhagic vocal cords with supraglott...
- CD5 positivity is an independent adverse prognosti...
- Impaired orthostatic blood pressure recovery and c...
- Evidence of the chemical reaction of 18O-labeled n...
- Endovascular techniques for the management of wide...
- Stimulant medication and postural orthostatic tach...
- Evaluation of the relationship between maxillary s...
- CME: Parkinson-Therapie zwischen Leitlinie und Ind...
- Scoping review of complexity theory in health serv...
- Val/Val glutathione-S-transferase P1 polymorphism ...
- Achieving behaviour change for detection of Lynch ...
- Patient information and emotional needs across the...
-
▼
Μαρ 12
(50)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
▼
2016
(16402)
- ► Δεκεμβρίου (7478)
-
▼
Μαρτίου
(850)
-
▼
Μαρ 12
(50)
- Genetic progression of malignant melanoma
- miR clusters target cellular functional complexes ...
- Personalized treatment of advanced non-small-cell ...
- Shear Wave Elastography and Cervical Lymph Nodes: ...
- Risk of second cancers in the era of modern radiat...
- Characterization of class II β chain major histoco...
- In Memoriam: Dr. William John Garrett, AM
- Presenting hydrothorax predicts failure of needle ...
- Do trauma patients with phencyclidine positive uri...
- Gap Between Official Guidelines and Clinical Pract...
- Error Rates, Decisive Outcomes and Publication Bia...
- Renal cell carcinoma: staging and surveillance
- Imaging wisely: patient safety in CT
- Abdominal radiology in the era of the Intervention...
- Comparison of hepatocellular carcinoma conspicuity...
- The “manta ray” pelvis
- The emotional rollercoaster of battling cancer – P...
- THYROID STIMULATING ANTIBODIES ARE HIGHLY PREVALEN...
- Ethical Considerations When Counseling Patients Wi...
- Utility of Diagnostic Molecular Markers for Evalua...
- Ethical Considerations When Counseling Patients Wi...
- En bloc resection of a C-1 lateral mass osteosarco...
- The Preventable Shunt Revision Rate: a potential q...
- Implications of patient-borne costs associated wit...
- Anti-CD137 monoclonal antibodies and adoptive T ce...
- Fate of Coiled Aneurysms with Minor Recanalization...
- Endovascular Management of Tandem Occlusion Stroke...
- Performance of CT ASPECTS and Collateral Score in ...
- Evaluating Permeability Surface-Area Product as a ...
- Quantitative Susceptibility Mapping in Cerebral Ca...
- Risk factors for persistent disease in papillary t...
- Rise in differentiated thyroid cancer incidence in...
- Treatment patterns of adjuvant interferon-[alpha]2...
- The Merits of a Two-Day Evidence-Based Medicine Co...
- Risk factors for persistent disease in papillary t...
- Assessment of Vibratory Characteristics in Childre...
- MULTIFOCAL CHOROIDITIS IN DISSEMINATED SPOROTRICHO...
- Patterns of lymphatic spread and the management of...
- Bilateral haemorrhagic vocal cords with supraglott...
- CD5 positivity is an independent adverse prognosti...
- Impaired orthostatic blood pressure recovery and c...
- Evidence of the chemical reaction of 18O-labeled n...
- Endovascular techniques for the management of wide...
- Stimulant medication and postural orthostatic tach...
- Evaluation of the relationship between maxillary s...
- CME: Parkinson-Therapie zwischen Leitlinie und Ind...
- Scoping review of complexity theory in health serv...
- Val/Val glutathione-S-transferase P1 polymorphism ...
- Achieving behaviour change for detection of Lynch ...
- Patient information and emotional needs across the...
-
▼
Μαρ 12
(50)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου