Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty.

Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty.

J Clin Endocrinol Metab. 2016 May 23;:jc20161545

Authors: Lippincott MF, Chan YM, Delaney A, Morales DR, Butler JP, Seminara SB

Abstract
CONTEXT: Some patients with idiopathic hypogonadotropic hypogonadism (IHH) undergo spontaneous activation of their hypothalamic-pituitary-gonadal axis resulting in normalization of steroidogenesis and/or gametogenesis, a phenomenon termed reversal.
OBJECTIVE: To assess the responsiveness of the GnRH neuronal network to exogenous kisspeptin administration in IHH patients who have undergone reversal.
PARTICIPANTS: Six men with congenital IHH and evidence for reversal.
INTERVENTION: Subjects underwent q10 min blood sampling to measure GnRH-induced LH secretion at baseline and in response to intravenous boluses of kisspeptin (0.24 - 2.4 nmol/kg) and GnRH (75 ng/kg).
RESULTS: Individuals with sustained reversal of their hypogonadotropism (spontaneous LH pulses) responded to exogenous kisspeptin with a GnRH-induced LH pulse. Individuals who had reversal but then subsequently suffered relapse of their IHH (loss of spontaneous LH pulsatility) did not respond to kisspeptin.
CONCLUSIONS: The ability of kisspeptin to stimulate a GnRH-induced LH pulse correlates with the presence of endogenous LH pulses. This data suggests that reversal of hypogonadotropism, and by extension, sexual maturation, may be due to the acquisition of kisspeptin responsiveness.

PMID: 27214398 [PubMed - as supplied by publisher]

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