Blastic plasmacytoid dendritic cell neoplasm: A case report and literature review.

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Blastic plasmacytoid dendritic cell neoplasm: A case report and literature review.

Exp Ther Med. 2016 Jul;12(1):319-322

Authors: Zhang YW, Zhong JH, Chen XL, Xiao F, Chen FY

Abstract
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a clinically aggressive tumor, which frequently presents as cutaneous lesions and subsequently progresses to bone marrow (BM) involvement and leukemic dissemination. BPDCN is a rare entity that belongs in the same class as acute myeloid leukemia-associated precursor neoplasms, according to the 2008 World Health Organization classification. The present study reported the case of a 26-year-old female who presented with evident thrombocytopenia, leukocytosis and anemia, but without skin lesions. The results of peripheral blood, BM smear and BM biopsy examinations detected numerous blastic or abnormal cells. In addition, flow cytometric analysis of BM demonstrated the presence of plasmacytoid dendritic cell-neoplastic precursor cells (CD4+, CD56+, CD123+, CD304+ and human leukocyte antigen-DR+ phenotype).

PMID: 27347056 [PubMed - as supplied by publisher]

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