Contrast enhanced ultrasonography used for post-treatment responses evaluation of radiofrequency ablations for hepatocellular carcinoma: a meta-analysis.

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Contrast enhanced ultrasonography used for post-treatment responses evaluation of radiofrequency ablations for hepatocellular carcinoma: a meta-analysis.

Br J Radiol. 2016 Jun 21;:20150973

Authors: Shi W, He Y, Ding W, Gong S, Wang Y, Xiao J, He B

Abstract
OBJECTIVES: This meta-analysis aims to analyze the usefulness of contrast enhanced ultrasonography (CEUS) for post-treatment responses evaluation of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) management.
METHODS: Literature retrieval in three databases PubMed, Embase and Cochrane Library, was conducted up to September 2015, with predefined criteria. The technical success rate, local tumor recurrence, local tumor progression were the measurement indexes. Cochran's Q test and I(2) were used for heterogeneity detection. Subgroup analyses were performed for complete ablation rate stratified by study designs, contrast agents and postoperative testing time points. Statistical analyses were conducted using Stata 12.0 software.
RESULTS: Twelve studies consisting of 772 patients were enrolled in this study. The CEUS evaluated success rate of RFA for HCCs was 91%. The proportion of ablative margin < 5 mm was 53%. The local tumor recurrence rate and local tumor progression rate were 4% and 8%, respectively. Subgroup analysis indicated that the CEUS assessed technical success rate with Sonazoid as contrast agent was higher (95%) than those with other agents (SH U 508A 86%; SonoVue 87%). The success rate assessed within 24 h (94%) after treatment was higher than longer time (1-3 days 86%; 1 month 91%).
CONCLUSION: The meta-analysis showed that the CEUS evaluated success rate of RFA for HCCs was 91%. The local tumor recurrence rate and local tumor progression rate were 4% and 8%, respectively.
ADVANCES IN KNOWLEDGE: Using meta-analysis, the study provided more reliable assessment of usefulness of CEUS, which could provide guidelines for HCC treatment.

PMID: 27327401 [PubMed - as supplied by publisher]

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