Iodinated Contrast Media-Induced Thyroid Dysfunction in Euthyroid Nodular Goiter Patients.

Iodinated Contrast Media-Induced Thyroid Dysfunction in Euthyroid Nodular Goiter Patients.

Thyroid. 2016 Jun 17;

Authors: Kornelius E, Chiou CY, Yang YS, Lo SC, Peng CH, Lai YR, Huang CN

Abstract
BACKGROUND: The risks of thyroid dysfunction after iodinated contrast media exposure in patients with euthyroid nodular goiter are largely unknown.
METHODS: This observational, retrospective cohort study included a random selection of 1 million people in Taiwan. All patients with iodinated contrast media exposure during this study period were selected. Patients with euthyroid nodular goiter were identified as cases, while patients without thyroid nodule were selected as controls. We followed these patients until the first event of thyroid dysfunction including hyperthyroidism or hypothyroidism after iodinated contrast media exposure.
RESULTS: A total of 334 cases and 2,672 matched controls were selected in this study. The mean age of cases and controls were 58.6 and 58.4 years old, and mean follow-up durations were 2.1 and 2 years, respectively. After adjustment, patients with euthyroid nodular goiter had higher risk of thyroid dysfunction (HR 5.43, 95% CI 3.01-9.80) compared with controls after iodinated contrast media exposure. In the subgroup analysis, the risks of hyperthyroidism and hypothyroidism in cases compared with controls were 5.77 (95% CI 2.64-12.62) and 4.95 (95% CI 2.15-11.40), respectively. Half of the euthyroid nodular goiter cases developed thyroid dysfunction within one year after iodinated contrast media exposure. Interestingly, all thyroid-related comorbidities and drug prescriptions did not increase the risk of thyroid dysfunction.
CONCLUSIONS: Presence of euthyroid nodular goiter was associated with higher risk of thyroid dysfunction, including hyperthyroidism and hypothyroidism after iodinated contrast media exposure.

PMID: 27315873 [PubMed - as supplied by publisher]

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