Sarcoma-like tumor originating from oligodendroglioma.

Sarcoma-like tumor originating from oligodendroglioma.:

Sarcoma-like tumor originating from oligodendroglioma.

Brain Tumor Pathol. 2016 Jun 22;

Authors: Shoji T, Saito R, Kanamori M, Sonoda Y, Watanabe M, Tominaga T

Abstract
We present a case of sarcoma occurring at a site of resected oligodendroglioma without preceding radiotherapy or chemotherapy. Oligosarcoma occurring at sites of resected oligodendroglioma or anaplastic oligodendroglioma with sarcomatous components are rare. Although meningioma or sarcoma-like lesions are sometimes reported after glioma-targeted radiotherapy, those without preceding radiotherapy are quite rare. Moreover, cases of sarcoma without oligodendroglial components occurring at a site of resected oligodendroglioma have never been reported. In this case, fluorescent in situ hybridization analysis revealed 1p/19q co-deletion in both the first tumor and second tumors. Additionally, immunohistochemistry revealed mutated isocitrate dehydrogenase 1 in both tumors. Taken together, these findings suggest a monoclonal tumor origin. Consequently, this case may indicate a new mechanism of development of sarcomatous lesions occurring at the site of a resected glioma.

PMID: 27333891 [PubMed - as supplied by publisher]

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