PDPR Gene Expression Correlates with Exercise-Training Insulin Sensitivity Changes.

Purpose: Whole body insulin sensitivity (Si) typically improves following aerobic exercise training; however, individual responses can be highly variable. The purpose of this study was to use global gene expression to identify skeletal muscle genes that correlate with exercise-induced Si changes. Methods: Longitudinal cohorts from the Studies of Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) were utilized as Discovery (Affymetrix) and Confirmation (Illumina) of vastus lateralis gene expression profiles. Discovery (n=39; 21 men) and Confirmation (n=42; 19 men) cohorts were matched for age (52 +/- 8 vs. 51 +/- 10 yr), BMI (30.4 +/- 2.8 vs. 29.7 +/- 2.8 kg*m-2), and VO2max (30.4 +/- 2.8 vs. 29.7 +/- 2.8 mL/kg/min). Si was determined via intravenous glucose tolerance test pre- and post-training. Pearson product-moment correlation coefficients determined relationships between a) baseline and b) training-induced changes in gene expression and %[DELTA]Si after training. Results: Expression of 2454 (Discovery) and 1778 genes (Confirmation) at baseline were significantly (P

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