Resveratrol increases microRNA-130a expression to promote angiogenesis and improve heart functions in mice after myocardial infarction.

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Resveratrol increases microRNA-130a expression to promote angiogenesis and improve heart functions in mice after myocardial infarction.

Exp Mol Pathol. 2016 Oct 24;:

Authors: Tang G, Peng L, Qian G, Wang S, Hu H, Zhang X, Song G, Yao M, Zhai C

Abstract
BACKGROUND: Resveratrol, a polyphenol of natural compounds, has beneficial cardiovascular effects. Increased expression of miR-130a has been reported to attenuate cardiac remodeling after myocardial infarction (MI). We hypothesized that resveratrol via an miR-130a-dependent mechanism promotes angiogenesis and improves heart functions in mice after MI.
METHODS: The MI model was established in mice by ligation of left anterior descending coronary artery. The expression of miR-130a was examined by RT-qPCR. Angiogenesis was assessed by immunohistochemistry. Heart function was determined by echocardiography.
RESULTS: Resveratrol increased miR-130a expression, promoted cell proliferations and migrations in HUVECs, which were abolished by miR-130a antagomir or AMPK inhibitor Compound C. In mice following MI, administration of resveratrol significantly increased miR-130a expressional level, promoted angiogenesis, reduced infarct size, and improved heart functions after 14 postoperative days. Importantly, these in vivo effects of resveratrol were ablated by antagonism of miR-130a.
CONCLUSION: Resveratrol via upregulation of miR-130a promotes ischemia-induced angiogenesis and improves heart functions.

PMID: 27789328 [PubMed - as supplied by publisher]

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