A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites

Publication date: 21 November 2016
Source:Developmental Cell, Volume 39, Issue 4
Author(s): Michal Eisenberg-Bord, Nadav Shai, Maya Schuldiner, Maria Bohnert
Membrane contact sites enable interorganelle communication by positioning organelles in close proximity using molecular "tethers." With a growing understanding of the importance of contact sites, the hunt for new contact sites and their tethers is in full swing. Determining just what is a tether has proven challenging. Here, we aim to delineate guidelines that define the prerequisites for categorizing a protein as a tether. Setting this gold standard now, while groups from different disciplines are beginning to explore membrane contact sites, will enable efficient cooperation in the growing field and help to realize a great collaborative opportunity to boost its development.

Teaser

Membrane contact sites enable interorganellar communication by positioning two organelles in proximity through molecular "tethers." Determining just what is a tether has been challenging. Eisenberg-Bord, Shai et al. review known tether machineries and aim to delineate a gold-standard definition for categorizing a protein as a tether.


http://ift.tt/2gyhSTe