Anti-Müllerian Hormone reflects the severity of Polycystic Ovary Syndrome

Abstract

Objective

To examine the relationship between Anti-Müllerian Hormone (AMH) and the severity of the phenotype of patients with Polycystic Ovary Syndrome (PCOS) and whether AMH can act as a diagnostic marker for PCOS?

Design

A prospective diagnostic utility study of AMH as a marker of PCOS.

Patients

A consecutive series of women presenting to a tertiary infertility clinic (n=164) plus a second series of women prepared for assisted conception treatments (n=89), recruited between June 2012 and May 2013.

Measurements

PCOS was diagnosed using the Rotterdam criteria. AMH was measured using the Generation II assay (Beckmann Coulter). The diagnostic utility of AMH was established using receiver operator characteristic (ROC) curves. Cut off values for the individual features of PCOS are proposed.

Results

There was a significant difference in serum AMH concentration in women with normal ovaries (13.2 pmol/L), polycystic ovary morphology (PCOM) alone (37.8 pmol/L) and PCOS (53.2 pmol/l). Follicle number, increasing cycle length and evidence of hyperandrogenism were all independently associated with serum AMH concentration (p<0.01). AMH was significantly affected by the different phenotypic presentations of PCOS with those with all components (PCOM, HA and OA) having the highest mean value (72.7 pmol/L (p<0.01)).

Conclusions

Serum AMH has the capacity to act as a diagnostic test for PCOS. Moreover, since its value rises with the more marked phenotypes, different cut-off values need to be used to differentiate those patients with polycystic ovarian morphology (PCOM), hyperandrogenism (HA) and oligoanovulation (OA).

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