Clinical correlates of leukoaraiosis: A study of 175 patients

Rustom S Wadia, Sandesh K Ghiya, Joshita Singh, Santosh M Sontakke, Vishwas Bharadwaj, Rahul V Sonawane, Yogesh P Bade, K Shrikanth, Nikhil Goli, Rohit Singh Chauhan, Nilesh A Nadkarni

Annals of Indian Academy of Neurology 2016 19(4):478-481

Background: In India, the correlates of leukoaraiosis (LA) have not been widely reported. This study was designed to investigate the factors which correlate with LA. Materials and Methods: We included patients with LA who consented for the study and graded their severity on the basis of Fazekas scale. We excluded patients with LA who did not consent/cooperate for the study as also patients with other white matter changes which mimic LA. Results: LA is a common and under-rated cause of disability. Presentations include cognitive decline, gait disturbance, dysarthria, bladder/bowel sphincter disturbances, and increased risk of stroke. The comorbidities include hyperhomocysteinemia, hypertension, dyslipidemia, tobacco use, ischemic heart disease, previous stroke, atrial fibrillation, chronic renal failure, and bariatric surgery.

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