The Editors' Choice

Obesity is a risk factor for asthma development and aggravation. However, the mechanisms underlying this relationship remain unclear. In this issue, Everaere et al (p 1309) have identified type 2 and 3 innate lymphoid cells (ILCs) as being involved in asthma aggravation by obesity. The authors show that, compared with a low-fat diet, high-fat diet–induced obesity decreased the number of ILCs in mouse adipose tissue while concomitantly increasing it in the lungs in parallel to eosinophil infiltration.

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