Catalog of genetic progression of human cancers: non-Hodgkin lymphoma.

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Catalog of genetic progression of human cancers: non-Hodgkin lymphoma.

Cancer Metastasis Rev. 2016 Mar;35(1):109-27

Authors: Bödör C, Reiniger L

Abstract
The recent application of next-generation sequencing technologies lead to significant improvements in our understanding of genetic underpinnings of non-Hodgkin lymphomas with identification of an unexpectedly high number of novel mutation targets across the different B-cell lymphoma entities. These recently discovered molecular lesions are expected to have a major impact on development of novel biomarkers and targeted therapies as well as patient stratification based on the underlying genetic profile. This review will cover the major discoveries in B-cell lymphomas using next-generation sequencing technologies over the last few years, highlighting alterations associated with relapse and progression of these diseases.

PMID: 26957091 [PubMed - indexed for MEDLINE]

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