[Double-Hit Follicular Lymphoma with BCL2 and MYC Translocations].

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[Double-Hit Follicular Lymphoma with BCL2 and MYC Translocations].

Gan To Kagaku Ryoho. 2016 Sep;43(9):1135-8

Authors: Horiuchi M, Fuseya H, Tsutsumi M, Hayashi Y, Hagihara K, Kanashima H, Nakao T, Fukushima Y, Inoue T, Yamane T

Abstract
Double-hit lymphomas are rare tumors that are defined by a chromosomal breakpoint affecting the MYC/8q24 locus in combination with another recurrent breakpoint, mainly a t(14; 18)(q32;q21)involving BCL2. We report a case of a 38-yearold woman with a 2-month history of abdominaldistention. 18F-FDG PET showed multiple positive systemic lymph nodes, positive peritoneum, and multiple positive intra-abdominal masses. Histopathology results of the cervical lymph node were compatible with double-hit follicular lymphoma(Grade 3A)because fluorescence in situ hybridization(FISH)demonstrated both MYC rearrangement and BCL2 gene fusion. She was initially started on R-CHOP(rituximab and doxorubicin, vincristine, cyclophosphamide, and prednisolone), but after one course the regimen was changed to dose-adjusted EPOCH-R(rituximab and doxorubicin, etoposide, vincristine, cyclophosphamide, and prednisolone). However, she showed no response to this chemotherapy regimen or haploidentical stem cell transplantation. The treatment strategy included salvage chemothera- py. An autologous and/or allogeneic hematopoietic transplantation is important for non-responders to DA-EPOCH-R.

PMID: 27628560 [PubMed - indexed for MEDLINE]

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