miR-644a inhibits cellular proliferation and invasion via suppression of CtBP1 in gastric cancer cells.

miR-644a inhibits cellular proliferation and invasion via suppression of CtBP1 in gastric cancer cells.

Oncol Res. 2016 Oct 27;:

Authors: Li Y, Yan X, Ren L, Li Y

Abstract
Epithelial to mesenchymal transition (EMT) is one of the most important reasons for the metastasis of various cancers,including gastric cancer (GC). In this study, we will explore the putative significance of miR-644a and its role in EMT-mediated metastasis of GC. Firstly, we detected the expression of miR-644a in a cohort of 107 GC tissues using quantitative RT-PCR. The expression of miR-644a was suppressed in GC tissues, and was related with later clinical stage and tumor metastasis. Restoring the expression of miR-644a could significantly suppress the migration and invasion of HGC-27 and SGC-7901 cells, which might be correlated with its suppressive effects on the EMT procedure. We also found that carboxyl-terminal binding protein 1 (CtBP1) was a putative target gene of miR-644a in GC, and might be involved in the suppressive effects. Collectively, through targeting CtBP1-mediated suppression of EMT procedure, miR-644a might suppress the tumor metastasis of GC cells.

PMID: 27983935 [PubMed - as supplied by publisher]

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