Mold and dampness exposure and allergic outcomes from birth to adolescence: data from the BAMSE cohort

Abstract

Background

Exposure to moldy or damp indoor environments is associated with allergic disease in young children, but it is unclear if the effects persist to adolescence. Our objective was to assess if exposure to mold or dampness during infancy increases the risk of asthma, rhinitis, or IgE sensitization in children followed from birth to 16 years of age.

Methods

We collected questionnaire derived reports of mold or dampness indicators and allergic outcomes from 3798 children in a Swedish birth cohort (BAMSE). Sensitization was assessed from blood samples in 3293 children. Longitudinal associations between prevalent asthma, rhinitis, and IgE sensitization and mold or dampness indicators were assessed using generalized estimating equations.

Results

Exposure to any mold or dampness indicator was associated with asthma up to age 16 years (OR 1.31; 95%CI 1.08–1.59), while exposure to mold odor (OR 1.29; 95%CI 1.03–1.62) and visible mold (OR 1.28; 95%CI 1.04–1.58) were associated with rhinitis.

Increased risks were observed for non-allergic asthma (OR 1.80; 95%CI 1.27–2.55) and rhinitis (OR 1.41; 95%CI 1.03–1.93). No association was observed between mold or dampness indicators and IgE sensitization. Exposure to any mold or dampness indicator was associated with persistent asthma (OR 1.73; 95%CI 1.20–2.50), but not with early-transient, or late-onset asthma.

Conclusion

Exposure to mold or dampness during infancy increased the risk of asthma and rhinitis to age 16 years, particularly for non-allergic disease. Early exposure to mold or dampness appeared particularly associated with persistent asthma through adolescence.

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