A conceptually novel construction of the 6a-hydroxypterocarpan skeleton – synthesis of (±)-variabilin

Publication date: Available online 5 January 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Philipp Ciesielski, Peter Metz
A new access to the 6a-hydroxypterocarpan variabilin was established. Key step of this concise total synthesis is a challenging cyclization of a haloketone via halogen–metal exchange and subsequent intramolecular addition to the carbonyl function.

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