Σφακιανάκης Αλέξανδρος
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Πέμπτη 19 Ιανουαρίου 2017

A novel method linking neural connectivity to behavioral fluctuations: Behavior-Regressed Connectivity

Publication date: Available online 18 January 2017
Source:Journal of Neuroscience Methods
Author(s): Antony D. Passaro, Jean M. Vettel, Jonathan McDaniel, Vernon Lawhern, Piotr J. Franaszczuk, Stephen M. Gordon
BackgroundDuring an experimental session, behavioral performance fluctuates, yet most neuroimaging analyses of functional connectivity derive a single connectivity pattern. These conventional connectivity approaches assume that since the underlying behavior of the task remains constant, the connectivity pattern is also constant.New MethodWe introduce a novel method, behavior-regressed connectivity (BRC), to directly examine behavioral fluctuations within an experimental session and capture their relationship to changes in functional connectivity. This method employs the weighted phase lag index (WPLI) applied to a window of trials with a weighting function. Using two datasets, the BRC results are compared to conventional connectivity results during two time windows: the one second before stimulus onset to identify predictive relationships, and the one second after onset to capture task-dependent relationships.ResultsIn both tasks, we replicate the expected results for the conventional connectivity analysis, and extend our understanding of the brain-behavior relationship using the BRC analysis, demonstrating subject-specific BRC maps that correspond to both positive and negative relationships with behavior.Comparison with Existing Method(s): Conventional connectivity analyses assume a consistent relationship between behaviors and functional connectivity, but the BRC method examines performance variability within an experimental session to understand dynamic connectivity and transient behavior.ConclusionThe BRC approach examines connectivity as it covaries with behavior to complement the knowledge of underlying neural activity derived from conventional connectivity analyses. Within this framework, BRC may be implemented for the purpose of understanding performance variability both within and between participants.



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