Acid-suppressive medications during pregnancy and risk of asthma and allergy in children: A systematic review and meta-analysis

Acid-suppressive medications, such as H2-receptor antagonists (H2RA) and proton pump inhibitors (PPI), are the main treatment options for dyspepsia and gastroesophageal reflux disease. These are common problems in pregnancy.1 Recently, concerns have been raised that prenatal exposure to these medications may increase the risk of allergic disease in the offspring.1 Dehlink et al1 were the first to report these associations, proposing that use of acid-suppressive medications in pregnancy may increase the risk of allergic disease in the offspring through interference with maternal digestion of labile antigens, thereby increasing the amount of allergen to which the fetus is exposed.

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