Association between the 20210G>A prothrombin gene polymorphism and arterial ischemic stroke in children and young adults – two meta-analyses of 3586 cases and 6440 controls in total

Publication date: Available online 4 January 2017
Source:Pediatric Neurology
Author(s): Beata Sarecka-Hujar, Ilona Kopyta, Michal Skrzypek, Joanna Sordyl
BackgroundPrevious data have shown that the 20210G>A polymorphism of the Factor II gene is related to an elevated prothrombin level, which may in turn lead to a procoagulant state. The heterogeneous and multifactorial character of arterial ischemic stroke (AIS) often results in contradictory reports describing the association between the 20210G>A polymorphism and AIS in different populations. We performed a meta-analysis of available data addressing the relation between the FII 20210G>A polymorphism and AIS, both in young adults and children.MethodsWe searched PubMed using appropriate keywords. The inclusion criteria for the study were as follows: case-control study, study population consisting of children, study population consisting of young adults, AIS confirmed by magnetic resonance imaging (MRI) or computed tomography (CT), English language. The exclusion criteria included: lack of genotype or allele frequencies, study design other than a case-control study, outcome definition other than AIS, previously overlapped patient groups. Finally, 30 case-control studies (14 in children and 16 in young adults) were included. Statistical analyses were conducted using R software. Heterogeneity between the studies was evaluated using the Dersimonian and Laird's Q test. In the case of significant between-studies heterogeneity, the pooled odds ratio (OR) was estimated with a random effects model, otherwise a fixed effects model was used.ResultsThe pooled analysis showed that carriers of 20210A allele (GA+AA genotypes) of the prothrombin gene are more common in AIS patients, both in children and young adults, than in controls (p=0.006,OR=1.83 95%CI 1.19-2.80 and p=0.001,OR=1.69 95%CI 1.25-2.28, respectively).ConclusionsThe results of the present meta-analysis have proven that the FII 20210G>A polymorphism is associated with AIS in both paediatric and young adult patients.



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