Consanguinity and the risk of Hashimoto's Thyroiditis.

Consanguinity and the risk of Hashimoto's Thyroiditis.

Thyroid. 2017 Jan 06;:

Authors: Zaghlol R, Haghighi A, Alkhayyat M, Farhan O, Owaydah A, Massad M, Atari M, Zayed AA

Abstract
BACKGROUND: Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease that may lead to hypothyroidism due to progressive destruction of thyroid. The etiology of HT is unclear. However, it is associated with multiple genetic predispositions. Consanguinity has been associated with an increased susceptibility to different inherited conditions. This study, for the first time, investigated the association between consanguinity and risk of HT.
METHODS: Using a case-control study design, we compared 298 HT patients with two subject groups; a) 299 participants with non-HT hypothyroidism, and b) 298 healthy control participants. The three groups were age and gender matched. Presence of consanguinity among the parents was compared in these groups and odds ratios were calculated to establish a correlation.
RESULTS: Consanguinity significantly increased the risk of HT (compared to healthy subjects; odds ratio= 3.3, p<0.0001). In addition, consanguinity was a significant risk factor for HT in hypothyroidism patients (odds ratio = 2.8, p<0.0001). However, the prevalence of consanguinity was not significantly different in non-HT hypothyroidism patients and healthy subjects.
CONCLUSIONS: The results suggest that the risk for HT is increased in consanguineous unions, but no significant increase in the risk of non-HT hypothyroidism was observed. However, for more precise risk estimates, larger studies that include different populations may be helpful. These findings highlight the health impact of consanguinity and have applications in empiric risk estimations in genetic counseling, particularly in countries with high rates of consanguineous marriages.  .

PMID: 28061551 [PubMed - as supplied by publisher]

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