Abstract: Immunotherapy targeting the programmed cell death 1 (PD-1) receptor has demonstrated tremendous promise in the treatment of advanced solid tumors. Dermatologic toxicities, however, are an emerging consequence of this therapy and have been clearly associated with immune checkpoint blockade antibodies. Distinctive clinical and histologic subtypes of dermatologic toxicity secondary to immunotherapy are emerging and include rare autoimmune bullous reactions (eg, bullous pemphigoid) and lichenoid eruptions. We report three patients who developed lichenoid dermatitis while receiving anti-PD-1 antibody therapy. The mean time to onset of lichenoid dermatologic toxicity was 42 days (range: 1–75 days) from initiation of anti-PD-1 antibody therapy. Lesions most frequently presented on the extremities and trunk as pustules, papules, and plaques. The face was not commonly involved. Of the five skin biopsies examined, all demonstrated dense band-like lymphocytic infiltrate, hyperkeratosis, hypergranulosis, saw-tooth rete ridge pattern, and dyskeratosis. Acanthosis was a feature in all of the skin biopsies, and in one, epidermal hyperplasia was prominent. In several skin biopsies, histologic features supporting a lichenoid drug eruption were present, including parakeratosis, spongiosis, periadnexal/perivascular inflammation, and eosinophils. Furthermore, the histologic features varied in skin biopsy specimens taken from the same patient at different sites, supporting a drug reaction. All patients' skin lesions improved with use of steroids: two were treated with topical steroids and one with systemic steroids. Recognition of the histopathologic patterns of dermatologic toxicities resulting from immune checkpoint blockade therapy will become increasingly important for ensuring appropriate management of dermatologic toxicities and optimal patient care.
http://ift.tt/2jOTMnZ
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
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Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- Structure-property relationships in ZnO:Al-hydroqu...
- Xeroderma Pigmentosum with Severe Neurological Man...
- Long-Term Follow-Up for Differentiated Thyroid Car...
- Long-Term Follow-Up for Differentiated Thyroid Car...
- Contribution of image-guided adaptive brachytherap...
- Monitoring of the posterior cricoarytenoid muscle ...
- Rurality and determinants of hearing healthcare in...
- In Response to “Does the intraoperative nerve moni...
- Extracapsular dissection as sole therapy for small...
- Monitoring of the posterior cricoarytenoid muscle ...
- Rurality and determinants of hearing healthcare in...
- In Response to “Does the intraoperative nerve moni...
- Extracapsular dissection as sole therapy for small...
- Melanin-concentrating hormone in peripheral circul...
- Binding of the chemokine CXCL12α to its natural ex...
- Limiting the protein corona: A successful strategy...
- Selective transduction of astrocytic and neuronal ...
- IOP-details
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- Instructions to Authors
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- Biocompatibility of polymer-infiltrated-ceramic-ne...
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- High-strength silk fibroin scaffolds with anisotro...
- Sequence distribution and elastic properties of pr...
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- Neutron diffraction study of conducting polyanilin...
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- Investigation into dielectric behaviour and electr...
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- A Near-peer Point-of-care Ultrasound Elective for ...
- Is p16 an adequate surrogate for human papillomavi...
- Genetic signature and profiling of head and neck c...
- The VHI-10 and VHI Item Reduction Translations—Are...
- Nasopharyngeal Adenocarcinoma: a Population-Based ...
- Hearing loss in Meniere's disease
- Nasopharyngeal Adenocarcinoma: a Population-Based ...
- Hearing loss in Meniere's disease
- Antibiotic therapy in critically ill patients: exp...
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- Antibiotic therapy in critically ill patients: exp...
- Intraoperative monitoring of analgesia using nocic...
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- APIC Masthead
- Editorial Board
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- Knowledge of Ebola virus disease among a universit...
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- The new frontier of diagnostics: Molecular assays ...
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- Traffic-related air pollution and allergic disease...
- Experimental comparison between tractional and com...
- Flagellar filament structural protein induces Sjög...
- Geriatric Oral and Maxillofacial Dysfunctions in t...
- Differential effects of the combination of tyrosol...
- Ameloblastoma: Current Etiopathological Concepts a...
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- The role of parotid gland irradiation in the devel...
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- Maternal Concentrations of Perfluoroalkyl Substanc...
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