Abstract: Primary oral mucosal melanoma is an extremely rare and aggressive tumor arising from melanocytes located in the mucosal epithelium of the oral cavity. Although malignant melanoma of oral mucosa shares some clinical features with its cutaneous counterpart, it has been associated with a worst prognosis; its etiopathogenesis are still only partially unraveled as there is no influence of UV radiation. It is known that the mitogen-activated protein kinase pathway mediates cellular responses to growth signals and its activation is an important phenomenon in melanoma. The aim of this study was to evaluate NRAS and BRAF genes, both components of mitogen-activated protein kinase molecular pathway, and compare with their protein expression. Point mutations of NRAS (codons 12, 13, and 61) and BRAF (codon 600) were screened by pyrosequencing method, and its results were associated to the protein expression of RAS and BRAF performed by immunohistochemistry. The authors observed mutation in BRAF 600 (3/14), NRAS codons 12 and 13 (2/14), and NRAS codon 61 (2/8). One case showed positive RAS protein expression, but no mutation was observed. Twelve in 14 cases showed positive BRAF protein expression: 3 cases showed BRAF mutation; 2 cases showed NRAS codon 61 mutation; 2 cases showed NRAS codons 12 and 13 mutation but not simultaneously. Although NRAS and BRAF mutation frequency and RAS protein expression are low, BRAF protein expression was intense; probably, NRAS and BRAF mutations are independent events and alternative molecular mechanisms in the primary oral mucosal melanoma tumorigenesis.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- The effects of microalloying on the precipitate mi...
- Microstructure evolution and mechanical properties...
- Self-assembly of quaternized chitosan nanoparticle...
- Structure-property relationships in ZnO:Al-hydroqu...
- Xeroderma Pigmentosum with Severe Neurological Man...
- Long-Term Follow-Up for Differentiated Thyroid Car...
- Long-Term Follow-Up for Differentiated Thyroid Car...
- Contribution of image-guided adaptive brachytherap...
- Monitoring of the posterior cricoarytenoid muscle ...
- Rurality and determinants of hearing healthcare in...
- In Response to “Does the intraoperative nerve moni...
- Extracapsular dissection as sole therapy for small...
- Monitoring of the posterior cricoarytenoid muscle ...
- Rurality and determinants of hearing healthcare in...
- In Response to “Does the intraoperative nerve moni...
- Extracapsular dissection as sole therapy for small...
- Melanin-concentrating hormone in peripheral circul...
- Binding of the chemokine CXCL12α to its natural ex...
- Limiting the protein corona: A successful strategy...
- Selective transduction of astrocytic and neuronal ...
- IOP-details
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- Instructions to Authors
- Correlation between auditory brainstem response an...
- Biocompatibility of polymer-infiltrated-ceramic-ne...
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- High-strength silk fibroin scaffolds with anisotro...
- Sequence distribution and elastic properties of pr...
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- Nanofiltration properties of asymmetric membranes ...
- Neutron diffraction study of conducting polyanilin...
- Cross-linked, polyurethane-based, ammonium poly(io...
- Investigation into dielectric behaviour and electr...
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- A Near-peer Point-of-care Ultrasound Elective for ...
- Is p16 an adequate surrogate for human papillomavi...
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- The VHI-10 and VHI Item Reduction Translations—Are...
- Nasopharyngeal Adenocarcinoma: a Population-Based ...
- Hearing loss in Meniere's disease
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- Antibiotic therapy in critically ill patients: exp...
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- APIC Masthead
- Editorial Board
- Information for Readers
- Knowledge of Ebola virus disease among a universit...
- Information for Authors
- Updated resource: The APIC/JCR Infection Preventio...
- Table of Contents
- Longitudinal assessment of reprocessing effectiven...
- The new frontier of diagnostics: Molecular assays ...
- Infection control in the new age of genomic epidem...
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- Social media use for occupational lung disease.
- Update on asthma and cleaning agents.
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- A wide scope of new developments in occupational a...
- Traffic-related air pollution and allergic disease...
- Experimental comparison between tractional and com...
- Flagellar filament structural protein induces Sjög...
- Geriatric Oral and Maxillofacial Dysfunctions in t...
- Differential effects of the combination of tyrosol...
- Ameloblastoma: Current Etiopathological Concepts a...
- Editorial Board
- Early secondary bone grafting in children with alv...
- A novel computer system for the evaluation of naso...
- Evaluation of maxillary sinus after Le Fort I oste...
- A novel computer system for the evaluation of naso...
- The role of parotid gland irradiation in the devel...
- Epigenetics of oropharyngeal squamous cell carcino...
- Posterior Medial Canthal Thermoplasty.
- Dilated Superior Ophthalmic Vein: Clinical and Rad...
- Epigenetics of oropharyngeal squamous cell carcino...
- Association of Facebook Use With Compromised Well-...
- Indoor Tanning and Melanoma Risk: Long-Term Eviden...
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- Maternal Concentrations of Perfluoroalkyl Substanc...
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