Pembrolizumab’s Non-cross Resistance Mechanism of Action Successfully Overthrown Ipilimumab

Publication date: Available online 7 January 2017
Source:Critical Reviews in Oncology/Hematology
Author(s): Mohd Wahid, Naseem Akhter, Arshad Jawed, Sajad A. Dar, Raju K. Mandal, Mohtashim Lohani, Mohammed Y. Areeshi, Saif Khan, Shafiul Haque
The incidences of melanomas are increasing by leaps and bounds across the globe despite early detection and intervention. The numbers of patients dying from metastatic melanoma have been continually increased over the past thirty years. It has been considered as one of the most therapy-resistant malignancies due to the cross-resistant mechanism developed by the metastatic cells. With time, many new therapies came and they failed miserably. Ipilimumab, a monoclonal antibody that works to activate the immune system by targeting CTLA-4 proved to be a boon for advance melanoma very recently. But it could not stand firmly against the resistant metastatic skin cancer cells. Now, the new skin cancer drug named pembrolizumab proved as a new miraculous molecule. It's a humanized monoclonal antibody that blocks a biological pathway called programmed cell death-1 (PD-1), which melanoma cells activate to suppress the immune system. This antibody has surpassed ipilimumab at all the stages of clinical trials because of its non-cross resistant mechanism to malignant cells. The present review critically analyzes the reasons of efficacy success of pembrolizumab over ipilizumab shown at various stages of clinical trials.



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