Preparation and biological evaluation of (99m)Tc-HYNIC-(Ser)3-D4 peptide for targeting and imaging of non-small-cell lung cancer.

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Preparation and biological evaluation of (99m)Tc-HYNIC-(Ser)3-D4 peptide for targeting and imaging of non-small-cell lung cancer.

Future Oncol. 2017 Jan 23;:

Authors: Haddad Zahmatkesh M, Abedi SM, Hosseinimehr SJ

Abstract
AIM: In this study, radiolabeled D4 peptide conjugate was studied as a radiotracer for imaging of non-small-cell lung cancer with overexpression of EGFR.
METHODS: HYNIC-(Ser)3-D4 peptide was labeled with (99m)Tc using tricine as a co-ligand. Cellular specific binding and internalization as well as in vivo tumor targeting were assessed.
RESULTS: The in vitro experiments showed good cellular specific binding. Tumor uptake values as %ID/g were 7.55 and 6.82% at 1 and 4 h after injection, respectively. The presaturation of EGFR in xenografted nude mice reduced 36% tumor uptake of radioactivity at 1 h after injection that confirmed in vivo specificity.
CONCLUSION: Findings showed this radiolabeled peptide is a promising candidate for tumor targeting and molecular imaging of non-small-cell lung cancer.

PMID: 28110557 [PubMed - as supplied by publisher]

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