Regression of gastric de novo diffuse large B-cell lymphoma following Helicobacter pylori eradication: a case report.

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Regression of gastric de novo diffuse large B-cell lymphoma following Helicobacter pylori eradication: a case report.

Acta Gastroenterol Belg. 2016 Jul-Sep;79(3):367-369

Authors: Saito M, Masutani M, Mabe K, Izumiyama K, Mori A, Irie T, Tanaka M, Morioka M, Tanino M

Abstract
We report a case of primary gastric diffuse large B-cell lymphoma (DLBCL), de novo DLBCL without the features of mucosa-associated lymphoid tissue (MALT) lymphoma, which regressed after Helicobacter pylori (HP) eradication. A 27-year-old Japanese female with epigastralgia was revealed to have ulcerated lesions in the angle and antral regions on gastroscopy. Biopsy specimen was consistent with a diagnosis of DLBCL without MALT lymphoma component, indicating de novo development. Her clinical staging on the Lugano system was Stage I. HP was positive on a rapid urease test, and she received HP eradication therapy twice, because the first therapy was not successful. On gastroscopy performed 1 month after the second HP eradication therapy, no ulcerated lesion was noted, and the lymphoma cells had regressed histopathologically. (Acta gastro-enterol. belg., 2016, 79, 367-369A).

PMID: 27821034 [PubMed - indexed for MEDLINE]

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