Regulatory roles of brain-specific angiogenesis inhibitor 1(BAI1) protein in inflammation, tumorigenesis and phagocytosis: a brief review

Publication date: Available online 16 January 2017
Source:Critical Reviews in Oncology/Hematology
Author(s): Vivek Bhakta Mathema, Kesara Na-Bangchang
Brain-specific angiogenesis inhibitor (BAI) family of proteins are basically putative G-protein-coupled receptors with wide spectrum of cellular activities. These BAIs exhibit intricate and complex nature of modulatory activities that researchers are only now beginning to understand. Here we mainly focus on the regulatory activities of a prominent member of BAI family, BAI1, with respect to its role in inflammation, tumorigenesis and phagocytosis. The emerging knowledge on cell- and site-specific function of BAI1 makes it both versatile and promising candidate for studies relating to cancer and host immune response. This review collectively specifies and comprehends important findings of BAI1 from several studies and provides latest insight to explore its properties for possible biomedical therapeutics.



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