Publication date: Available online 27 February 2017
Source:The Journal of Steroid Biochemistry and Molecular Biology
Author(s): Anita Kumar, Kushaan Dumasia, Sharvari Deshpande, N.H. Balasinor
Steroid hormones, estrogen and androgen, control transcription in various reproductive and non-reproductive tissues. Both hormones are known to be important for control of sperm release from the seminiferous epithelium (spermiation), a process characterized by extensive remodeling of actin filaments and endocytosis. Earlier studies with an estrogen (E2)-induced rat model of spermiation failure revealed genes involved in actin remodeling (Arpc1b and Evl) and endocytosis (Picalm, Eea1 and Stx5a) to be differentially regulated. Further, among these genes, Arpc1b and Evl were found to be estrogen-responsive while Eea1 and Stx5a were androgen-responsive and Picalm was responsive to both hormones in seminiferous tubule cultures. Yet, the mechanism by which these genes are regulated by estrogen and androgen in the testis was unclear. Here, we report the presence of a functional estrogen response element (ERE) upstream of Arpc1b and Evl genes and androgen response element (ARE) upstream of Picalm, Eea1 and Stx5a genes. Chromatin immunoprecipitation in control versus E2-treated testes revealed significant changes in estrogen receptor beta (ERβ) recruitment along with coregulators to the EREs upstream of Arpc1b and Evl genes and androgen receptor (AR) at AREs upstream of Picalm, Eea1 and Stx5a genes. Enrichment patterns of these EREs/AREs with coregulators, activating and repressing histone modifications along with RNA polymerase II recruitment correlated with the observed expression patterns of these genes upon E2 treatment. Taken together, our results reveal direct targets of estrogen and androgen in the testes and provide insights into transcriptional control of sperm release by the two steroid hormones.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
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00302841026182
00306932607174
alsfakia@gmail.com
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Direct regulation of genes involved in sperm release by estrogen and androgen through their receptors and coregulators
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- A Critical Role of Inhibition in Temporal Processi...
- Relapsing bullous amyloidosis of the oral mucosa a...
- A novel mutation in the RSPO4 gene in a patient wi...
- Otophyma in Morbihan disease
- Lentigo maligna successfully treated with combinat...
- Effectiveness of omalizumab in a case of urticaria...
- Relapsing bullous amyloidosis of the oral mucosa a...
- A novel mutation in the RSPO4 gene in a patient wi...
- Otophyma in Morbihan disease
- Lentigo maligna successfully treated with combinat...
- Effectiveness of omalizumab in a case of urticaria...
- Management of pinna of haematoma study (MaPHaeS): ...
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