Publication date: Available online 27 February 2017
Source:The Journal of Steroid Biochemistry and Molecular Biology
Author(s): Rosamaria Lappano, Marcello Maggiolini
The aggressiveness of breast tumors is deeply influenced by the surrounding stroma. In this regard, the functional crosstalk between cancer cells and the tumor microenvironment has received considerable attention in recent years. Cancer-associated fibroblasts (CAFs) are active components of the tumor stroma as they play a main role in the initiation, progression, metastasis and recurrence of breast malignancy. Hence, a better understanding of the mechanisms through which host stroma may contribute to cancer development would lead to novel therapeutic approaches aimed to target both tumor cells and the adjacent microenvironment. The G protein estrogen receptor (GPER/GPR30) has been involved in estrogenic signaling in normal and malignant cells, including breast cancer. It is noteworthy that the potential of GPER to mediate stimulatory effects of estrogens has been also shown in CAFs derived from patients with breast tumors, suggesting that GPER may act at the cross-road between cancer cells and these important components of the tumor microenvironment. This review recapitulates recent findings underlying the breast tumor-promoting action of CAFs, in particular their functional liaison with breast cancer cells via GPER toward the occurrence of malignant features.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Τρίτη 28 Φεβρουαρίου 2017
GPER is involved in the functional liaison between breast tumor cells and cancer-associated fibroblasts (CAFs)
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- Characterization of White Matter Tracts by Diffusi...
- Variations in Acetylcholinesterase Activity within...
- Mirroring the Social Aspects of Speech and Actions...
- A Critical Role of Inhibition in Temporal Processi...
- Relapsing bullous amyloidosis of the oral mucosa a...
- A novel mutation in the RSPO4 gene in a patient wi...
- Otophyma in Morbihan disease
- Lentigo maligna successfully treated with combinat...
- Effectiveness of omalizumab in a case of urticaria...
- Relapsing bullous amyloidosis of the oral mucosa a...
- A novel mutation in the RSPO4 gene in a patient wi...
- Otophyma in Morbihan disease
- Lentigo maligna successfully treated with combinat...
- Effectiveness of omalizumab in a case of urticaria...
- Management of pinna of haematoma study (MaPHaeS): ...
- Management of pinna of haematoma study (MaPHaeS): ...
- Poor Safety and Tolerability Hamper Reaching a Pot...
- Follicular lymphoma transforming into diffuse larg...
- Direct resin composite restorations for fractured ...
- Cytotoxicity and genotoxicity of a low-shrinkage m...
- Evaluation of dental adhesive systems incorporatin...
- Effect of monomer type on the CC degree of convers...
- Laryngopharyngeal Reflux in Children with Chronic ...
- Low-grade intraductal carcinoma (low-grade cribrif...
- Genomic profiling of esophageal squamous cell carc...
- Organic contaminants and heavy metals in indoor du...
- Two 3D Zinc(II) coordination frameworks constructe...
- Rising incidence of oral tongue cancer among white...
- Complications following transoral robotic surgery ...
- Clonal analysis as a prognostic factor in multiple...
- JAAA CEU Program.
- Validation of a Computer-Administered Version of t...
- Inner Ear Excitation in Normal and Postmastoidecto...
- Potential Benefits of an Integrated Electric-Acous...
- Does Language Matter When Using a Graphical Method...
- Evaluation of the Self-Fitting Process with a Comm...
- Build a Better Hearing Assessment and the Patients...
- An Update on Lower Lid Blepharoplasty
- Oculofacial Plastic and Reconstructive Surgery
- Pediatric Blepharoptosis
- Orbital Fracture Repair
- Intermediate-Acting Nondepolarizing Neuromuscular ...
- Clinical Evaluation of Blepharoptosis: Distinguish...
- Safety of Large-Volume, Same-Day Oral Bowel Prepar...
- Cross-Disciplinary Perceptions of Structured Inter...
- A Randomized Crossover Study Comparing Cervical Sp...
- Nonsurgical Rejuvenation of the Eyelids with Hyalu...
- Anesthetic Management for Percutaneous Minimally I...
- Orbital Decompression for Thyroid Eye Disease
- The Role of NR2B-CREB-miR212/132-CRTC1-CREB Signal...
- Ocular Adnexal Reconstruction for Cutaneous Perioc...
- Prophylactic Phenylephrine Infusions to Reduce Sev...
- Douglas P. Marx, MD
- Upper Eyelid Blepharoplasty: Evaluation, Treatment...
- Effect of Clopidogrel on Thrombus Formation in an ...
- Game-based combined cognitive and neurofeedback tr...
- Enzymatic extraction and characterization of polys...
- Smart Earbuds: A Looming Threat to the Hearing Aid...
- Emotional Soundscapes of Life With Ménière's Disease
- World Hearing Day
- Online Reputation Management for a Busy Clinic
- Detecting Non-Organic Hearing Loss at CI Assessment
- Listen to the Brain to Suss Out Concussions
- P-E Fit Increases in Importance for Older Patients
- Benefits of Extended High-Frequency Audiometry for...
- Promoting Hearing Health Care in Nepal
- Audiology Services for PSAP Users
- Symptom: Ear Blockage
- Trade Talk: A Q&A with Tucker Worster
- Hearing Conservation Through Partnership With Musi...
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- Brusterhaltende Therapie mit adjuvanter Radiothera...
- Clinical relevance of the M1b and M1c descriptors ...
- A 2-bp insertion (c.67_68insCC) in MC1R causes rec...
- Editorial Board
- Improvement in the diagnosis of catheter-related b...
- APIC Masthead
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- Foam soap is not as effective as liquid soap in el...
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- Are hospital floors an underappreciated reservoir ...
- Surveillance culture for multidrug-resistant gram-...
- Reasons for influenza vaccination underuse: A case...
- In this issue
- The importance of nano-porosity in the stalk-deriv...
- Self-assembly of mesoporous Bi-S-TiO 2 composites ...
- Evaluation of Coronary Artery Disease Using Myocar...
- TLR4/MD2 specific peptides stalled in vivo LPS-ind...
- Editorial board
- Crossing kingdoms: Using decellularized plants as ...
- New Classification System for Tear Trough Deformity.
- Vibration Anesthesia for Pain Reduction During Int...
- Reply to Blood Aspiration Test for Cosmetic Filler...
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