HLA DRB1*03 as a possible common etiology of schizophrenia, Graves' disease, and type 2 diabetes.

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HLA DRB1*03 as a possible common etiology of schizophrenia, Graves' disease, and type 2 diabetes.

Ann Gen Psychiatry. 2017;16:7

Authors: Sayeh A, Ben Cheikh C, Mardessi A, Mrad M, Nsiri B, Oumaya A, Fekih-Mrissa N

Abstract
BACKGROUND: Autoimmune diseases and schizophrenia share many common features. Association studies confirm a shared genetic association in the human leukocyte antigen (HLA) region between schizophrenia and most autoimmune diseases. To our knowledge, the simultaneous syndromes of Graves' disease (GD) and type 2 diabetes (T2D) in schizophrenia are rare in Tunisia.
CASE PRESENTATION: We report a case of a 42-year-old woman admitted to the department of psychiatry for an acute relapse of chronic schizophrenia. Her medical history revealed that she was followed for Graves' disease and for a type 2 diabetes mellitus. A low-resolution HLA typing was performed by polymerase chain reaction sequence-specific primer (PCR-SSP) techniques according to determine the patient's haplotype.
CONCLUSIONS: Our study suggests that the HLA DRB1*03 allele may explain a common etiology underlying the co-morbidity of Graves' disease, type 2 diabetes, and schizophrenia in our patient.

PMID: 28174595 [PubMed]

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