New drug development in head and neck squamous cell carcinoma: The PI3-K inhibitors

Publication date: April 2017
Source:Oral Oncology, Volume 67
Author(s): Francesca De Felice, Teresa Guerrero Urbano
Over the last few years a number of new different compounds have been developed. They include phosphatidylinositol 3-kinase (PI3-K) inhibitors. Deregulation within the PI3-K pathway is common in head neck squamous cell carcinoma (HNSCC) and it represents a growing area of research. PI3-K inhibitors, including BKM120, PX-866 and BYL719, are being tested in several phase I and phase II studies in patients with locally advanced, recurrent or metastatic disease.This review provides an update of published clinical trials and highlights the challenges of PI3-K inhibitors in HNSCC.



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