Publication date: Available online 22 February 2017
Source:Pathology - Research and Practice
Author(s): Jun-tao Yao, Qiu-ping Liu, Mo-qi Lv, Dang-xia Zhou, Zi-jun Liao, Ke-jun Nan
Circular RNAs (circRNAs) are a novel type of endogenous RNAs featuring stable structure and high tissue-specific expression. Recently, accumulating evidence has revealed that aberrant circRNAs expression plays important roles in carcinogenesis and tumor progression. However, the expression pattern and biological function of circRNAs in non small cell lung cancer (NSCLC) remain largely unknown. Therefore, the purpose of this study was to clarify the possible role of one of typical circRNAs, circRNA_100876 in NSCLC and to define its prognostic value in NSCLC. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of circRNA_100876 in tumor tissues and their adjacent nontumorous tissues in 101 patients with NSCLC. We found that the expression level of circRNA_100876 were significantly elevated in NSCLC tissues when compared with their adjacent nontumorous tissues (P=0.000). Moreover, there was a close correlation between the circRNA_100876 up-regulation expression and lymph node metastasis (P=0.001) and tumor staging (P=0.001) in NSCLC. In addition, Kaplan-Meier survival analysis demonstrated that the overall survival time of NSCLC patients with high circRNA_100876 expression was significantly shorter than those patients with low circRNA_100876 expression (P=0.000). In conclusion, our findings indicate that circRNA_100876 is closely related to the carcinogenesis of NSCLC and it might be served as a potential prognostic biomarker and therapeutic target for NSCLC.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- Naturally-occurring fatigue and cardiovascular res...
- Event-related theta oscillatory substrates for fac...
- The Concerted Action of Type 2 and Type 3 Deiodina...
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- The efficiency and adverse events of radiotherapy ...
- Over-expression of CircRNA_100876 in non-small cel...
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Τετάρτη 22 Φεβρουαρίου 2017
Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value
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- Glucagon-like peptide-1 (GLP-1) increases in plasm...
- Long Time No See: Enduring Behavioral and Neuronal...
- Gβ2 Regulates the Multipolar-Bipolar Transition of...
- Higher Striatal Iron Concentration is Linked to Fr...
- Neuronal and Peripheral Pentraxins Modify Glutamat...
- Low-Rank and Sparse Decomposition Based Shape Mode...
- Editorial Board
- EACMFS Prizes and Awards
- Announcements
- Contemporary management of carotid blowout syndrom...
- Carotid blowout syndrome in patients treated by la...
- Carotid blowout syndrome after nasopharyngeal carc...
- Stereotactic Body Radiation Therapy for Recurrent ...
- Anesthetic Management During Emergency Surgical Li...
- A limited thoracocervical approach for accessing t...
- Timely Antecedent CT or MRI Can Help Predict Hemor...
- A novel approach to the management of carotid blow...
- Postprandial dysmetabolism: assessment and treatment.
- Preoperative markers in differentiated thyroid can...
- Outcomes of interventions for carotid blowout synd...
- Preoperative markers in differentiated thyroid can...
- Defining optimal vitamin D cut-off levels: Τhe rol...
- Emerging treatment modalities for advanced pancrea...
- Calcium homeostasis in women with non-metastatic b...
- Young adult patient with headache, fever and blurr...
- Urinary steroid metabolites in a case of florid Ec...
- A new TRβ mutation in resistance to thyroid hormon...
- Low-risk papillary thyroid carcinoma patients who ...
- A novel approach to the management of carotid blow...
- The depiction of acromegaly in ancient Greek and H...
- A novel mutation of the calcium-sensing receptor g...
- Severe osteoporosis with multiple spontaneous vert...
- Parathyroid hormone response to severe vitamin D d...
- Leydig cell clustering and Reinke crystal distribu...
- Thyroid hormones: a potential ally to LDL-choleste...
- Glycemic control in patients with insulinoma.
- Muscular effects of vitamin D in young athletes an...
- Prevention and Treatment of Life-Threatening Bleed...
- Defining optimal vitamin D cut-off levels: Τhe rol...
- Emerging treatment modalities for advanced pancrea...
- Endovascular Management of Post-Irradiated Carotid...
- Carotid blowout and cerebral gas embolism related ...
- Hyperfractionated stereotactic reirradiation for r...
- Fatal carotid blowout syndrome after BNCT for head...
- Massive Epistaxis from Internal Carotid Pseudoaneu...
- Carotid blowout syndrome in pharyngeal cancer pati...
- Covered Stents for the Prevention and Treatment of...
- Carotid blowout syndrome.
- Endovascular treatment of carotid artery blowout s...
- Honokiol protects skin cells against inflammation,...
- Expression levels of transcription factor PU.1 and...
- Aims and Scope & Editorial Board
- The Concerted Action of Type 2 and Type 3 Deiodina...
- Applying Criteria of Active Surveillance to Low-Ri...
- The efficiency and adverse events of radiotherapy ...
- Naturally-occurring fatigue and cardiovascular res...
- Event-related theta oscillatory substrates for fac...
- The Concerted Action of Type 2 and Type 3 Deiodina...
- Applying Criteria of Active Surveillance to Low-Ri...
- The efficiency and adverse events of radiotherapy ...
- Over-expression of CircRNA_100876 in non-small cel...
- Sensitivity of tumor surface brushings to detect h...
- Evaluation of the Effects of Photobiomodulation on...
- Phototoxicity of Vascular Endothelial Cells Caused...
- Comparison of Three Final Irrigation Activation Te...
- Analysis of Human Tooth Pulp Chamber Temperature A...
- The multimorbid polysensitized phenotype is associ...
- Reply
- Dermal morphological changes following salicylic a...
- Comparison of digital panoramic radiography versus...
- Dermal morphological changes following salicylic a...
- Comparison of digital panoramic radiography versus...
- Wogonin, a plant derived small molecule, exerts po...
- Single-Beam Acoustic Trapping of Red Blood Cells a...
- Computer-Based Algorithmic Determination of Muscle...
- The Correlation of Arterial Stiffness with Biophys...
- Alanine Aminotransferase Is a Marker of Lipotoxici...
- Significant differences of function and expression...
- Randomized study on the effect of single-implant v...
- Synthesis of clarithromycin ketolides chemically m...
- Identification of compounds with cytotoxic activit...
- Design and synthesis of selective CDK8/19 dual inh...
- Synthesis of native-like crosslinked duplex RNA an...
- The efficiency and adverse events of radiotherapy ...
- Providing Feedback
- Exosomes derived from human amniotic epithelial ce...
- Adjuvant chemotherapy in patients with locoregiona...
- Acceptable regret model in the end-of-life setting...
- Ovarian Ablation for Premenopausal Breast Cancer: ...
- Systematic analysis of early phase clinical studie...
- Cutaneous Lymphadenoma: A Trichoblastoma with Regr...
- Trends in Nasal Subunit Reconstruction by Facial P...
- Delayed Facial Nerve Paralysis following Blast Trauma
- Nasal Anatomy and Function
- Principles of Nasal Reconstruction
- Using Grafts and Granulation to Improve Nasal Repair
- Nasal Reconstruction
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