Patient-reported control of chronic rhinosinusitis symptoms is positively associated with general health-related quality of life

Abstract

Objective

In chronic rhinosinusitis (CRS), although patient-reported severity of sinonasal symptoms is significantly associated with diminishment of patients' general health-related quality of life (QOL), it remains unclear whether patient-perceived control of CRS symptomatology is associated with patients' QOL. In this study, we sought to determine the association between patient-perceived control of CRS symptomatology and QOL.

Design

Prospective cross-sectional study.

Setting

Academic, tertiary care center.

Participants

A cohort of 166 adults with CRS who were asked to categorize their level of CRS symptom control as "Not at all", "A little", "Somewhat", "Very" and "Completely".

Main outcome measure

General health-related QOL, as reflected by the 5-dimensional EuroQol quality of life survey-derived visual analog scale (EQ5D-VAS) and health utility values (EQ5D-HUV).

Results

We found that higher EQ5D-VAS scores were associated with CRS patients who classified their symptom control as "Very" (adjusted β = 15.74, 95%CI: 5.44 – 26.04, p=0.003) and "Completely" (adjusted β= 14.24, 95%CI: 2.98 – 25.52, p=0.014) compared to patients who classified their symptom control as "Not at all". This was also true for higher EQ5D-HUV which was associated with patient-reported CRS symptom control of "A little" (adjusted β = 0.10, 95%CI: 0.01 – 0.18, p=0.024), "Somewhat" (adjusted β = 0.08, 95%CI: 0.00 – 0.17, p=0.049), "Very" (adjusted β = 0.13, 95%CI: 0.05 – 0.21, p=0.002) and "Completely" (adjusted β=0.18, 95%CI: 0.09 – 0.27, p<0.001).

Conclusions

Higher levels of patient-reported CRS symptom control are therefore associated with better QOL. These findings suggest that CRS symptom control should be targeted for improving patients' QOL.

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