Publication date: Available online 20 February 2017
Source:Annals of Allergy, Asthma & Immunology
Author(s): Stella Hartono, Megan S. Motosue, Shakila Khan, Vilmarie Rodriguez, Vivek N. Iyer, Rohit Divekar, Avni Y. Joshi
BackgroundA subset of patients with common variable immunodeficiency (CVID) develop granulomatous lymphocytic interstitial lung disease (GLILD), which is associated with early mortality.ObjectiveTo determine a set of clinical and/or laboratory parameters that correlate with GLILD.MethodsA retrospective, nested case-control (patients with CVID diagnosed with GLILD compared with patients with CVID without a diagnosis of GLILD) medical record review was undertaken at Mayo Clinic, Rochester, MN. Network and univariate analysis was used to identify clinical and laboratory parameters at the time of diagnosis that are associated with GLILD.ResultsTwenty-six cases with radiologic evidence of GLILD were included in this study. Eighteen cases (69%) cases had coexistent splenomegaly with lower IgA levels (P = .04) compared with the controls. Patients with low IgA levels (<13 mg/dL) also had percentage expansion of low CD21 B cells (CD21low >5%) (P = .007). Univariate analysis revealed that splenomegaly (odds ratio [OR], 17.3; 95% confidence interval [CI], 3.9–74.5), history of immune thrombocytopenic purpura (ITP) or autoimmune hemolytic anemia (AIHA) (OR, 4.8; 95% CI, 1.1–20.2), low IgA level (OR, 3.6; 95% CI, 1.2–11.9), and percentage expansion of CD21low (OR, 5.8; 95% CI, 1.6–24.7) were independently associated with GLILD. Logistic regression analysis revealed that splenomegaly, history of ITP or AIHA, low IgA level, and percentage expansion of CD21low B cells are highly sensitive in predicting presence of GLILD (area under the receiver operating curve of 0.86).ConclusionPresence of splenomegaly, history of ITP or AIHA, low serum IgA level, and percentage expansion of CD21low B cells may be useful to identify a group of patients at high risk for development of GLILD.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Τρίτη 21 Φεβρουαρίου 2017
Predictors of granulomatous lymphocytic interstitial lung disease in common variable immunodeficiency
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- Pepsin as a biomarker for laryngopharyngeal reflux...
- The effects of venous ensheathment on facial nerve...
- The current status of human laryngeal transplantat...
- Pepsin as a biomarker for laryngopharyngeal reflux...
- Clinical effect of intratympanic dexamethasone inj...
- The current status of human laryngeal transplantat...
- Customized software to optimize circumferential ph...
- Clinical effect of intratympanic dexamethasone inj...
- Laboratory assessment of sudden sensorineural hear...
- Customized software to optimize circumferential ph...
- Quality of life of patients who underwent aestheti...
- Laboratory assessment of sudden sensorineural hear...
- Compound motor action potential duration and laten...
- Quality of life of patients who underwent aestheti...
- The repeatability of tests of eustachian tube func...
- Compound motor action potential duration and laten...
- Impacts of disease severity on postoperative compl...
- The repeatability of tests of eustachian tube func...
- Intranasal trigeminal function in patients with em...
- Impacts of disease severity on postoperative compl...
- Scoping review: Awareness of neurotoxicity from an...
- Intranasal trigeminal function in patients with em...
- Can contaminated water be rendered safe for nasal ...
- Scoping review: Awareness of neurotoxicity from an...
- The feasibility of NBI in patients with suspected ...
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- Erratum
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- Erratum
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- The emotional, social, and financial burden of foo...
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- Can the burden of disease due to food allergy be p...
- Regulating dynamic signaling between hematopoietic...
- A randomized study of BI 671800, a CRTH2 antagonis...
- For the Patient
- Response to inhaled corticosteroids on serum CD28,...
- A single injection of protein-loaded coacervate-ge...
- Erratum
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- Understanding alpha-1 antitrypsin deficiency: A re...
- The emotional, social, and financial burden of foo...
- The National Institutes of Allergy and Infectious ...
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- American Academy of Asthma, Allergy & Immunology m...
- Relation of indoor and outdoor airborne fungal spo...
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