Sarcomatoid carcinoma of the common bile duct: A case report.

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Sarcomatoid carcinoma of the common bile duct: A case report.

Medicine (Baltimore). 2017 Jan;96(3):e5751

Authors: Zhang S, Jia J, Bi X, Jiang Q, Zhao Y, Chen Y, Xu Q, Lan Z, Zhang J, Zhang Z, Wang C

Abstract
RATIONALE: Sarcomatoid carcinoma is an extremely rare lesion in the common bile duct (CBD).
PATIENT CONCERNS: We present a case of sarcomatoid carcinoma of the distal CBD in a 51-year-old woman who presented with jaundice and abdominal pain. Whipple's operation was performed successfully. Microscopically, the tumor was a poorly differentiated carcinoma containing a component of sarcoma-like differentiation. The tumor cells displayed spindle-shaped nuclei with occasional mitotic figures. Cytokeratin (CK) 7, CK19, CK18, and pan-CK (AE1/AE3) staining was positive on immunohistochemistry. Vimentin and carcinoembryonic antigen (CEA) staining were also positive.
DIAGNOSES: Sarcomatoid carcinoma of the distal CBD.
INTERVENTIONS: The patient received three cycles of chemotherapy after surgery.
OUTCOMES: The patient has experienced no adverse events in the 3 years post-surgery.
LESSONS: We present here a case report of sarcomatoid carcinoma of the distal CBD. The patient received chemotherapy after surgery, and was event-free for 3 years post-surgery, suggesting a relatively better prognosis, despite the infiltrative pattern of the tumor.

PMID: 28099333 [PubMed - indexed for MEDLINE]

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