The effect of adipose-derived stem cells on acellular dermal matrix engraftment in a rabbit model of breast reconstruction

Acellular dermal matrix (ADM) is frequently used in implant-based breast reconstruction. Though there are several advantages, ADM implantation also increases the risk of certain complications. Recently, ADM seeded with adipose-derived stem cells (ADSCs) were shown to induce angiogenesis and improve wound healing. This study aimed to investigate the effects of ADSCs on ADM engraftment in a rabbit model of implant-based breast reconstruction.Silicone implants were inserted to submuscular pocket of 16 female New Zealand rabbits using ADM with or without seeding of fluorescent PKH26-labelled rabbit ADSCs.

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