A novel mitochondria-targeted near-infrared fluorescence probe for ultrafast and ratiometric detection of SO2 derivatives in live cells

Publication date: 1 June 2017
Source:Talanta, Volume 168
Author(s): Hui Huang, Wei Liu, Xian-Jun Liu, Yong-Qing Kuang, Jian-Hui Jiang
A novel mitochondria-targeted ratiometric near-infrared fluorescence probe NDMBT for Sulfur dioxide (SO2) derivatives was constructed based on the SO2 derivatives-triggered Michael addition reaction. It displayed ultrafast response time (within 10s), large hypsochromic shift (260nm), high photostability, excellent selectivity and high sensitivity in aqueous media with a detection limit of 43nM. More importantly, it was successfully applied to imaging of the enzymatically generated SO2 derivatives in mitochondria of live cells.

Graphical abstract

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