Comparison of DCE-MRI kinetic parameters and FMISO-PET uptake parameters in head and neck cancer patients.

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Comparison of DCE-MRI kinetic parameters and FMISO-PET uptake parameters in head and neck cancer patients.

Med Phys. 2017 Mar 20;:

Authors: Simoncic U, Leibfarth S, Welz S, Schwenzer N, Schmidt H, Reischl G, Pfannenberg C, la Fougère C, Nikolaou K, Zips D, Thorwarth D

Abstract
PURPOSE: Tumour hypoxia is a major cause of radiation resistance, often present in various solid tumours. Dynamic [(18) F]-fluoromisonidazole (FMISO) PET imaging is able to reliably assess tumour hypoxia. Comprehensive characterization of tumour microenvironment through FMISO-PET and dynamic contrast enhanced (DCE) MR multimodality imaging might be a valuable alternative to the dynamic FMISO-PET acquisition. The aim of this work was to explore the correlation between the FMISO-PET and DCE-MRI kinetic parameters.
METHODS: This study was done on N=6 head and neck cancer patients, who were imaged dynamically with FMISO-PET and DCE-MRI on the same day. Images were registered and analysed for kinetics on a voxel basis. FMISO-PET images were analysed with the two-tissue compartment three rate-constant model. Additionally, tumour-to-muscle ratio (TMR) maps were evaluated. DCE-MRI was analysed with the extended Tofts model. Voxel-wise Pearson coefficients were calculated for each patient to assess pairwise parameter correlations.
RESULTS: Median correlations between FMISO uptake parameters and DCE-MRI kinetic parameters varied across the parameter pairs in the range from -0.05 to 0.71. The highest median correlation of r=0.71 was observed for the pair Vb -vp , while the K1 -K(trans) median correlation was r=0.45. Median correlation coefficients for the K1 -vp and the Ki -K(trans) pairs were r=0.42 and r=0.32, respectively. Correlations between FMISO uptake rate parameter Ki and DCE-MRI kinetic parameters varied substantially across the patients, whereas correlations between the FMISO and DCE-MRI vascular parameters were consistently high. Median TMR-K1 and TMR-K(trans) correlations were r=0.52 and r=0.46, respectively, but varied substantially across the patients.
CONCLUSIONS: Based on this clinical evidence, we can conclude that the vascular fraction parameters obtained through DCE-MRI kinetic analysis or FMISO kinetic analysis measure the same biological property, while other kinetic parameters are unrelated. These results might be useful in the design of future clinical trials involving FMISO-PET/DCE-MR multimodality imaging for the assessment of tumour microenvironment. This article is protected by copyright. All rights reserved.

PMID: 28317128 [PubMed - as supplied by publisher]

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