Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
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Σάββατο 25 Μαρτίου 2017

Delay in diagnosis affects the clinical outcome in a cohort of cvid patients with marked reduction of iga serum levels

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Publication date: Available online 25 March 2017
Source:Clinical Immunology
Author(s): Graziano Vincenzo, Pecoraro Antonio, Mormile Ilaria, Quaremba Giuseppe, Genovese Arturo, Buccelli Claudio, Paternoster Mariano, Giuseppe Spadaro
Common variable immunodeficiency disorders (CVID) represent a collection of diseases leading to an absent or strongly impaired antibody production. CVID presents a wide range of immunological abnormalities and clinical manifestations, including infections, inflammatory and autoimmune diseases, and malignancies. The aim of this observational study was to analyze the epidemiological and clinical features of a cohort of 75 Italian CVID patients, and evaluate the correlation with comorbidity and mortality. Clinical data were retrospectively collected: the cohort was followed-up for a maximum of 30years (mean time of 10.24years, median of 9years). An higher age at the diagnosis of CVID and an higher age at onset of symptoms were significantly associated with a reduction of patients survival if stratified per median of IgA (less than or >8.00mg/dl). Thus IgA levels at diagnosis are correlated with patients survival contributing to identify a subset with a worse prognostic outcome.



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