Gastric cancer managment: Kinases as a target therapy.

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Gastric cancer managment: Kinases as a target therapy.

Clin Exp Pharmacol Physiol. 2017 Mar 07;:

Authors: Farran B, Müller S, Montenegro RC

Abstract
The molecular diagnostics revolution has reshaped the practice of oncology by facilitating the identification of genetic, epigenetic and proteomic modifications correlated with cancer, thus delineating 'oncomaps' for various cancer types. These advances have enhanced our understanding of gastric cancer, one of the most fatal diseases worldwide, and culminated in the approval of novel molecular therapies such as trastuzumab. Gastric tumours display recurrent aberrations in key kinase oncogenes such as Her2, EGFR, PI3K, mTOR or c-Met, suggesting that these receptors are amenable to inhibition using specific drug agents. In this review, we examine the mutational landscape of gastric cancer, the use of kinase inhibitors as targeted therapies in gastric tumours and the clinical trials underway for novel inhibitors, highlighting successes, failures and future directions. This article is protected by copyright. All rights reserved.

PMID: 28271563 [PubMed - as supplied by publisher]

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