Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy.

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Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy.

Thyroid. 2017 Mar 17;:

Authors: Wassner A, Jugo RH, Dorfman DM, Padera RF, Maynard MA, Zavacki AM, Jay PY, Huang S

Abstract
BACKGROUND: The thyroid hormone-inactivating enzyme type 3 deiodinase (D3) is induced during hypertrophic and ischemic cardiomyopathy, leading to a state of local cardiac hypothyroidism. Whether D3 induction occurs in dilated cardiomyopathy is unknown.
METHODS: We characterized changes in cardiac D3 and thyroid hormone signaling in a transgenic model of progressive dilated cardiomyopathy (TG9 mice).
RESULTS: Cardiac D3 was dramatically induced 15-fold during the progression of dilated cardiomyopathy in TG9 mice. This D3 induction localized to cardiomyocytes and was associated with a decrease in myocardial thyroid hormone signaling.
CONCLUSIONS: Cardiac D3 is induced in a mouse model of dilated cardiomyopathy, indicating that D3 induction may be a general response to diverse forms of cardiomyopathy.

PMID: 28314380 [PubMed - as supplied by publisher]

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