Normal PAI-2 level in French FXII-HAE patients

We read with interest the recent article by Joseph et al.1 Joseph et al explored plasminogen activator inhibitor (PAI)-1 and PAI-2 antigen levels in 23 patients with hereditary angioedema with normal C1 inhibitor (HAE-N) in remission; among them, 12 patients had FXII mutation. They observed a significant decrease in PAI-2 level in patients with HAE-N compared with control subjects; 11 out of 12 patients with HAE-N with FXII mutation had a marked decrease in PAI-2 levels. However, Joseph et al observed no statistically significant decrease in PAI-1 level compared with controls with a high interindividual variability.

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