PIFA–BF3·OEt2 mediated intramolecular regioselective domino cyclization of ynamides: A novel method for the synthesis of tetrahydroisoquinoline-oxazol-2(3H)-ones

Publication date: Available online 19 March 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Winai Ieawsuwan, Somsak Ruchirawat
The transition metal-free intramolecular regioselective domino cyclization of N-Boc protected ynamides has been developed to provide the corresponding tetrahydroisoquinoline-oxazo-2(3H)-ones in moderate to good yields.

Graphical abstract

http://ift.tt/2nqM1XL