Regulation of memory B and plasma cell differentiation

Publication date: April 2017
Source:Current Opinion in Immunology, Volume 45
Author(s): Ryo Shinnakasu, Tomohiro Kurosaki
Memory B cell generation and antibody production result from a differentiation process that begins when the surface BCR on naïve B cells binds an antigen. How the choice between these fates is tempo-spatially regulated is still obscure, but recent advances have reinforced the concept that the combination of B cell-intrinsic heterogeneity and -extrinsic heterogeneity provided by cells such as T cells is a key determinant. As molecular regulators, the transcription factors IRF4 and Bach2, which participate in these fate choices, have been emerging.



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