Publication date: Available online 9 March 2017
Source:Vaccine
Author(s): Eon E.K. Ting, Beate Sander, Wendy J. Ungar
BackgroundSeasonal influenza immunization programs vary widely across jurisdictions. In Canada, some provinces offer universal programs while others target specific population groups. However, whether targeted or universal programs provide more benefit and value-for-money is unclear. The cost-effectiveness of influenza immunization programs was systematically reviewed to inform policy.MethodsCitation databases and the grey literature were searched for economic evaluations of influenza immunization programs. Eligible studies were appraised using the Scottish Intercollegiate Guidelines Network (SIGN) checklist with supplemental WHO vaccine-related questions. Data from high quality studies was extracted and the studies reviewed.ResultsA total of 41influenza immunization studies were identified. Of these, 31 were high quality. For pregnant and postpartum women, vaccinating all versus only high risk women study results ranged from dominance (less costly and more effective) to $9773 per QALY gained (societal) and from dominance to $58,000 per QALY gained (healthcare system). Studies of vaccinating all versus only high risk children found vaccination to be dominant to $47,000 per QALY gained (societal), and dominant to $18,000 per QALY gained (healthcare system). Vaccinating high risk adults was highly cost-effective and vaccinating health care workers resulted in $35,000 per QALY gained. Results for healthy working adults were mixed and sensitive to vaccine uptake, efficacy, and productivity loss.ConclusionsFrom the societal perspective, vaccination was cost-effective for children, pregnant and postpartum women, high risk groups, and in some cases, healthy working age adults. Immunization programs using group administration are more cost-effective than programs using individual administration. The perspective, programmatic design, setting, and inclusion of herd immunity affects cost-effectiveness. In regions with targeted programs, re-evaluating "high risk" criteria and consideration of a universal program is warranted.
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ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- Voice and swallowing outcomes for adults undergoin...
- The use of practice guidelines in the management o...
- Self-reported postoperative recovery in children a...
- Foreign body aspiration in children: Focus on the ...
- Anti-angiogenic treatment for breast cancer?
- The role of drug-drug interactions in prostate can...
- Incidental Findings on Pediatric Abdominal Magneti...
- Dosimetric Analysis of Liver Toxicity Post Liver M...
- Outcomes and Toxicity following High-Dose Radiatio...
- Persistent nasal carriers of Acinetobacter baumann...
- A New Keystone Flap “Plus” Design: Case Series and...
- Failure to Diagnose an Incompetent Cervix,Prematur...
- Permanent prostate brachytherapy pubic arch evalua...
- Assessment of clinical and radiologic differences ...
- Use of hepatobiliary phase images in Gd-EOB-DTPA-e...
- Unusual ultrasound appearance of small bowel intus...
- Contrast-enhanced ultrasound and computed tomograp...
- Neocortical and hippocampal TREM2 protein levels d...
- Engineering intravaginal vaccines to overcome muco...
- Islet encapsulation with polyphenol coatings decre...
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- TANTIGEN: a comprehensive database of tumor T cell...
- Murine Th17 cells utilize IL-2 receptor gamma chai...
- Acoustic Context Alters Vowel Categorization in Pe...
- Verrucarin A and roridin E produced on spinach by ...
- Withdrawing ASV therapy in clinical practice: tria...
- Risk of developing obstructive sleep apnea among w...
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- Reactivating p53 and Inducing Tumor Apoptosis (RIT...
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- Using early life stages of marine animals to scree...
- Toxic effect of nonylphenol on the marine macroalg...
- Unique characteristics of algal dissolved organic ...
- Precipitation and air temperature control the vari...
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- Migration of nitrate, nitrite, and ammonia through...
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- Characterization of ferromagnetic sludge-based act...
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- Hypofractionated radiotherapy in older patients wi...
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- G protein-coupled calcium-sensing receptor is a cr...
- Tolerability, usability and acceptability of disso...
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- Proximal upper limb jerking: important clinical si...
- Graphene oxide functionalized long period grating ...
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- Label-free identification of activated T lymphocyt...
- Nanosphere-based one-step strategy for efficient a...
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