Publication date: Available online 8 March 2017
Source:Annals of Allergy, Asthma & Immunology
Author(s): Michelle L. North, Jeffrey R. Brook, Elizabeth Y. Lee, Vanessa Omana, Nadia M. Daniel, Lisa M. Steacy, Greg J. Evans, Miriam L. Diamond, Anne K. Ellis
BackgroundThe Kingston Allergy Birth Cohort (KABC) is a prenatally recruited cohort initiated to study the developmental origins of allergic disease. Kingston General Hospital was chosen for recruitment because it serves a population with notable diversity in environmental exposures relevant to the emerging concept of the exposome.ObjectivesTo establish a profile of the KABC using the exposome framework and examine parentally reported respiratory symptoms to 2 years of age.MethodsData on phase 1 of the cohort (n = 560 deliveries) were compiled, and multivariate Cox proportional hazards regression models were used to determine associations with respiratory symptoms.ResultsThe KABC exhibits diversity within the 3 exposome domains of general external (socioeconomic status, rural or urban residence), specific external (cigarette smoke, breastfeeding, mold or dampness), and internal (respiratory health, gestational age), as well as significant associations between exposures from different domains. Significant associations emerged between parental reports of wheeze or cough without a cold and prenatal cigarette smoke exposure, mold or dampness in the home, and the use of air fresheners in the early-life home environment. Breastfeeding, older siblings, and increased gestational age were associated with decreased respiratory symptoms.ConclusionThe KABC is a unique cohort with diversity that can be leveraged for exposomics-based studies. This study found that all 3 domains of the exposome had effects on the respiratory health of KABC children. Ongoing studies using phase 1 of the KABC continue to explore the internal exposome through allergy skin testing and epigenetic analyses and the specific external domain through in-home environmental analyses, air pollution modeling, and ultimately potential convergences within and among domains.
http://ift.tt/2nkYVUx
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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The Kingston Allergy Birth Cohort
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- Simvastatin-associated dermatomyositis
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- Issue Information
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- Estrogen modulates mesenchymal-epidermal interacti...
- The chromatin modifier Satb1 regulates cell fate t...
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- IP3R mediated Ca2+ release regulates protein metab...
- BRC1 expression regulates bud activation potential...
- Inhibition of ectopic microtubule assembly by the ...
- Helios expression coordinates the development of a...
- Helicobacter Pylori infection in Omani children
- Issue Information
- Analysis of Disease Activity Categories in Chronic...
- Analysis of Disease Activity Categories in Chronic...
- Search strategies for finding systematic reviews
- Search strategies for finding systematic reviews
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- Analysis of voice-related quality of life in children
- Cross-cultural adaptation of the Brazilian version...
- The C- terminal region of the Major Outer Sheath P...
- (A) Hematoxylin-eosin (×400). Lung parenchyma with...
- (A) Hematoxylin-eosin (×400). Lung parenchyma with...
- Changes in university orthodontic care over a peri...
- Thermal imaging of the pulp during residual adhesi...
- Three-dimensional analysis of mandibular condyle p...
- The accuracy of computer-guided piezocision: a pro...
- From the midnight sun to the longest night: sleep ...
- Branchial Arch Anomalies: Recurrence, Malignant De...
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- A Systematic Review of Complications Associated wi...
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- Changes in university orthodontic care over a peri...
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- Literacy Outcomes for Primary School Children Who ...
- The Quantal Larynx: The Stable Regions of Laryngea...
- Exploring Use of the Coordinate Response Measure i...
- Rhythm Perception and Its Role in Perception and L...
- Increased Response to Altered Auditory Feedback in...
- Compensatory Strategies in the Developmental Patte...
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