Analysis of application of docetaxel combined therapy scheme in treating advanced head and neck neoplasm.

Analysis of application of docetaxel combined therapy scheme in treating advanced head and neck neoplasm.

Pak J Pharm Sci. 2016 Nov;29(6(Special)):2231-2234

Authors: Nie L, Liu Y

Abstract
Docetaxel is a semi-synthetic taxoid anti-cancer drug, which can basically freeze intracellular skeleton that is composed of microtubules, so as to inhibit cell division. Under normal condition, Docetaxel can make microtubule in a cell cycle follow the rule of first polymerization and then depolymerization. Moreover, docetaxel can further promote the microtubule polymerization while inhibiting cell depolymerization, so as to prevent cells division, lead to cancer cells death, and improve the therapeutic efficiency of tumor and cancer. However, as a newly developed drug, docetaxel's specific clinical effect has not been fully verified yet. Therefore, in this research, 2000 patients of advanced head and neck neoplasm were selected as research objects, which were treated with docetaxel combined with DDP and fluorouracil. By observing indexes such as patient's condition, complication condition, and life quality, the clinical effect of docetaxel combined therapy scheme in treating head and neck neoplasm was analyzed. Results show that such therapy scheme is of sound therapeutic effect and high application value.

PMID: 28412686 [PubMed - in process]

http://ift.tt/2pp74es